Home News & Events News Base.128 and Base.128 RED at the EATB2011

Base.128 and Base.128 RED at the EATB2011





Our most recent studies on BASE.128 and BASE.128RED presented at the EATB 2011.

The annual meeting of the European Association of Tissue Banks, Barcelona, Spain, November 9-11, 2011, will be the best opportunity to learn more about the performances of BASE.128 and BASE.128RED, two effective products for decontamination of human tissues intended for transplantation, manufactured by AL.CHI.MI.A.


From July 2009 to June 2010, a number of serious adverse reactions and serious adverse events were reported from many different European countries. Also, a patient died in 2002 because of Clostridium sepsis, which was linked to the application of tissue graft. The investigation found out that the procedure was not validated to assure sterility and antibiotic residues interfered with the sterility test failing to detect tissue contamination.


We studied the optimal conditions to decontaminate and rinse human tissues (cardiovascular, skin) intended for transplantation with the aim of decontaminating effectively the tissue and minimizing the amount of residual antibiotics. Decontamination procedures with the BASE.128 product, which allows to remove both contaminants and antibiotic residues from tissues, were validated.

For more information on Base.128 and Base.128 RED, click here.

The following papers will be presented during the meeting:

• Terzi A., Buzzi M., Guarino A., Dainese L., Vasuri F., D’Amato Tóthová J., Gatto C.: Optimization of cardiovascular tissue decontamination and rinsing with BASE.128 and BASE.
• Vassanelli A., Bosinelli A., Rizzi S., Lucchini E., Gatto C., Giurgola L., D’Amato Tóthová, J.: Skin decontamination and impact of antibiotic residues on microbiological tests.
• Gatto C., Pianigiani E., Ierardi F., Giurgola L., D’Amato Tóthová, J.: Time-Kill studies of BASE.128 against S. Epidermidis II, S. Capitis and P. Acnes isolated from donor skin.
• Pianigiani E., Gatto C., Giurgola L., D’Amato Tóthová, J.: Establishment of a rinsing procedure to eliminate antibiotic and glycerol residues from cryopreserved skin decontaminated with BASE.128.
• Gatto C., Giurgola L., Beccaro M., Lipartiti M., D’Amato Tóthová, J.: Impact of antibiotic residues on microbiological analysis: implication of tissue banking.