BASE 128

What is BASE.128?

BASE•128 is a ready-to-use solution to decontaminate various human tissues intended for transplantation (cardiovascular, musculoskeletal, osteotendons, skin and amniotic membrane) in different conditions of time and temperature.

The mixture of four antibiotics (vancomycin, gentamicin, cefotaxime, and amphotericin B desoxycholate) is active against the most frequent contaminants detected in tissue banks (Gram positive and Gram negative bacteria, yeasts and moulds).

The BASE•128 decontamination solution can also be used for tissue transport to the bank, immediately after procurement, or during tissue dissection.

Intended use

DECONTAMINATION OF VARIOUS HUMAN TISSUES INTENDED FOR TRANSPLANTATION (CARDIOVASCULAR, MUSCULOSKELETAL, OSTEOTENDONS, SKIN AND AMNIOTIC MEMBRANE)

Characteristics

STERILE
PYROGEN-FREE
MYCOPLASMA-FREE
CE MARK: 0477

Technical Documents

CE Certificate 335.83 KB 2373 downloads

AL.CHI.MI.A. S.R.L. production quality system is compliant with Annex Il (excluding...

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Technical Sheet - BAS 005-00 491.61 KB 355 downloads

BASE•128 - 250 ml ...

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Technical Sheet - BAS 006-00 485.01 KB 240 downloads

BASE•128 - 500 ml ...

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Publications and Presentations

Logistics of an advanced therapy medicinal product during COVID-19 pandemic in Italy: successful delivery of mesenchymal stromal cells in dry ice
Year: 2020 Authors: Astori G.; Bernardi M.; Bozza A.; Catanzaro D.; Chieregato K.; Merlo A.; Santimaria M.; Barbazza R.; Amodeo G.; Ciccocioppo R.; Elice F.; Ruggeri M. J Transl Med 18, 451 (2020) doi.org/10.1186/s12967-020-02625-0 Online version This is a: Publication [...]
Strategies for tissue decontamination during umbical cord-derived mesenchymal stromal cells production and determination of antibiotic residues final product
Year: 2019, European Association of Tissue and Cell Banks (EATCB) Authors: Chieregato K.; Gatto C.; Alghisi A.; Bianchini G.; Bernardi M.; Bozza A.; Catanzaro D.; Giurgola L.; Lievore C.; Mozzo V.; Perbellini O.; Rassu [...]
Production of umbical cord-derived Mesenchymal stromal cells in an hospital based-GMP facility: from tissue collection to ATMP release
Year: 2019, European Association of Tissue and Cell Banks (EATCB) Authors: Chieregato K.; Alghisi A.; Bernardi M.; Bianchini G.; Bozza A.; Catanzaro D.; Lievore C.; Mozzo V.; Perbellini O.; Rassu M.; Ruggeri M.; Tagliaferri [...]
Sterility testing of tissue samples according to European Pharmacopoeia
Year: 2017, EATB Authors: Giurgola L.; Gatto C.; Molena S.; D’Amato Tóthová J. Purpose: The aim of this study was to validate the sterility testing of tissue samples according to the “Method suitability test” [...]
Comparison of impact of two decontamination solutions on the viability of the cells in human amnion
Year: 2017 Authors: Smeringaiova I.; Trosan P.; Mrstinova M. B.; Matecha J.; Burkert J.; Bednar J.; Jirsova K. Cell Tissue Bank: June 6, 2017 10.1007/s10561-017-9636-3 Online version This is a: Publication [...]
Decontamination of human larynx with medical device Base.128
Year: 2015, EATB Authors: Carvalho C.; Giurgola L.; Bartley H.; Proctor T.; Gatto C.; D’Amato Tóthová J.; Lowdell M. Background: The aim of the study was to investigate the decontamination of human donor larynx [...]
Decontamination of umbilical cord tissue with Base.128, Time-kill Studies
Year: 2015, EATB Authors: Giurgola L.; Gatto C.; Cabrita G.; Formosinho P.; D’Amato Tóthová J. Background: Decontamination of umbilical cord is a critical phase before cryopreservation. We investigated the decontamination efficacy of the [...]
Residual antibiotics in decontaminated human cardiovascular tissues intended for transplantation and risk of falsely negative microbiological analyses
Year: 2014 Authors: Buzzi M.; Guarino A.; Gatto C.; Manara S.; Dainese L.; Polvani G.; D’Amato Tóthová J. PLoS One. 2014 Nov 14;9(11):e112679. doi: 10.1371/journal.pone.0112679. eCollection 2014 Online version This [...]
Validation of “ResEP tube” system for microbiological analysis with removal of antibiotic residues
Year: 2013, EATB Authors: Giurgola L.; Gatto C.; D’Amato Tóthová J. Abstract: Residual antibiotic concentrations may induce bacteriostasis of microorganisms eventually present on tissue samples and lead to false negative results during microbiological analysis [...]
Validation of a device for elimination of antibiotics from liquid samples undergoing microbiological analysis
Year: 2013, BATB Authors: Giurgola L.; Gatto C.; Vassanelli A.; Guarino A.; Buzzi M.; D’Amato Tóthová J. Abstract: Our previous studies indicated that the use of antibiotic cocktails during tissue processing can lead to an [...]
Evaluation of different microbiological testing methods in tissue banking
Year 2013, EATB Authors: D’Amato Tóthová J.; Giurgola L.; Gatto C. Abstract: Each tissue bank validates its own method for microbiological analysis of tissues, which is essential to determine whether they can be released for [...]
A suitable and efficient procedure for the removal of decontaminating antibiotics from tissue allografts
Year: 2013 Authors: Gatto C.; Giurgola L.; D’Amato Tóthová J. Cell and Tissue Banking 14(1), 107-115, 2013 Online version This is a: Publication Abstract: The presence of residual antibiotics [...]
Impact of antibiotic residues on microbiological analysis: implication of tissue banking
Year: 2011, EATB Authors: Gatto C.; Giurgola L.; Beccaro M.; Lipartiti M.; D’Amato Tóthová, J. Abstract: Decontamination of tissue allografts in antibiotic cocktails can lead to an antibiotic carry-over effect, which in turn can result [...]
Establishment of a rinsing procedure to eliminate antibiotic and glycerol residues from cryopreserved skin decontaminated with BASE.128
Year 2011, EATB Authors: Pianigiani E.; Gatto C.; Giurgola L.; D’Amato Tóthová, J. Abstract: Skin decontamination and cryopreservation can result in the presence of antibiotic and glycerol residues, which shall be removed before transplantation [...]
Time-Kill studies of BASE.128 against S. Epidermidis II, S. Capitis and P. Acnes isolated from donor skin
Year: 2011, EATB Authors: Gatto C.; Pianigiani E.; Ierardi F.; Giurgola L.; D’Amato Tóthová, J. Abstract: We investigated the decontamination efficacy of BASE.128 against clinical isolates of the most frequent skin allograft contaminants. Our results [...]
Skin decontamination and impact of antibiotic residues on microbiological tests
Year: 2011, EATB Authors: Vassanelli A.; Bosinelli A.; Rizzi S.; Lucchini E.; Gatto C.; Giurgola L.; D’Amato Tóthová, J. Abstract: The performance of BASE.128 were compared to that of the antibiotic solution currently used [...]
Optimization of cardiovascular tissue decontamination and rinsing with BASE.128 and BASE
Year: 2011, EATB Authors: Terzi A.; Buzzi M.; Guarino A.; Dainese L.; Vasuri F., D’Amato Tóthová J.; Gatto C. Abstract: We studied the optimal conditions to decontaminate and rinse cardiovascular tissues intended for transplantation [...]
Validation of standardized industrial antibiotic cocktails
Year: 2010, Cardiovascular Tissue Bank Meeting Authors: Gatto C.; Giurgola L.; D’Amato Tóthová J. Abstract: The aim of the present study was to evaluate the performances of the industrial antibiotic cocktail BASE.128 as compared to [...]
Elimination of antibiotic carry-over from tissues decontaminated with Base.128
Year: 2010, EATB Authors: Gatto C.; Beccaro M.; Lipartiti M.; D’Amato Tóthová J. Abstract: Decontamination of tissue allografts in antibiotic cocktails can lead to the antibiotic carry-over effect, which in turn can result in [...]
Fate of antibiotics after tissue decontamination. Study on heart valves, pericardium, bone and skin
Year: 2010, BATB Authors: D’Amato Tóthová J.; Gatto C.; Cavallaro D.; Beccaro M.; Lipartiti M. Abstract: Elimination of residual antibiotics from allograft/human tissues intended for transplantation after decontamination is paramount to ensure tissue quality and [...]
Effects of tissue, time and temperature on decontamination efficacy of Base.128
Year: 2010, BATB Authors: D’Amato Tóthová J.; Gatto C.; Beccaro M.; Candeo L.; Bortoluzzi S.; Lipartiti M. Introduction: Decontamination is a crucial step in allograft processing. Tissue banks have established their own decontamination [...]
Comparison among the medical devices BASE.128, BASE, CRYO.ON and the solutions currently used in two Italian cardiovascular tissue banks
Year: 2010, EATB Authors: Gatto C.; Marchiani A.; Ruzza P.; Beccaro M.; D’Amato Tóthová, J. Abstract: We evaluated the performances of the HTP medical devices in comparison with solutions currently used by the Cardiovascular Tissue [...]
Fate of antibiotics after the tissue decontamination phase: Study on pig heart valves
Year: 2009, EATB Authors: D’Amato Tóthová J.; Gatto C.; Cavallaro D.; Beccaro M.; Lipartiti M. Abstract: Elimination of residual antibiotics from allograft/human tissues intended for transplantation after decontamination is paramount to ensure tissue quality [...]
Effects of temperature on decontamination efficacy of BASE.128 by in vitro Time-Kill studies
Year: 2009, EATB Authors: D’Amato Tóthová J.; Gatto C.; Beccaro M.; Candeo L.; Bortoluzzi S.; Lipartiti M. Abstract: Decontamination is a crucial step in allograft processing. Tissue banks have established decontamination procedures using different [...]

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Details

BASE

Packaging: Bottle
Items: 12
Volume: 500 ml

BASE is a rinsing solution able to remove antibiotics from various human tissues intended for transplantation (cardiovascular, musculoskeletal, osteotendons, skin and amniotic membrane) after [...]
Category: RinsingTissue banking

What is BASE.128?

Intended use

Characteristics

Technical Documents

CE Certificate 335.83 KB 2373 downloads

Technical Sheet - BAS 005-00 491.61 KB 355 downloads

Technical Sheet - BAS 006-00 485.01 KB 240 downloads

Publications and Presentations

Related products

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Request info about BASE.128

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