Impact of antibiotic residues on microbiological analysis: implication of tissue banking

Abstract: Decontamination of tissue allografts in antibiotic cocktails can lead to an antibiotic carry-over effect, which in turn can result in false negative in microbiological tests. Our investigation on the impact of antibiotic residues on microbiological analysis showed that a significant number of false negative results are found in tissues and liquid samples undergoing bacteriological analysis after decontamination. Our results suggest that both validation of the decontamination process and microbiological method is necessary to warrant  tissue safety.