Fate of antibiotics after the tissue decontamination phase: Study on pig heart valves

Abstract: Elimination of residual antibiotics from allograft/human tissues intended for transplantation after decontamination is paramount to ensure tissue quality and safety. We monitored the fate of antibiotics during the tissue processing phases after decontamination of pig heart valves in an antibiotic cocktail containing Vancomycin, Cefotaxime and Amphotericin B.